MEDD

Only small ships and yachts can access the harbor of Sète, which is one reason this enchanting French port has retained its many charms. The birthplace of numerous artists, including poet Paul Valéry and singer-songwriter Georges Brassens, Sète has a rich artistic heritage and its museums pay tribute. Colorfully painted façades line the town’s canals, which include the northeastern entrance to the Canal du Midi, a UNESCO World Heritage site linking the Mediterranean and Atlantic through southern France. Several other UNESCO sites nearby compete for attention.

Make sure to be on deck to witness sailing into one of the Aegean’s most spectacular sights: the volcanic caldera that is Santorini’s bay. Rising from the sea, the earth transforms into a wall of stone that looms in striating hues of ochres, grays and pinks. Dotted with the island’s iconic blue-domed churches, the whitewashed village of Fira hovers in the cliffs, bustling with shops, tavernas and a fine museum while clinging to the caldera’s rim.

An amazing amalgam of sights and sounds, Rome is a kinetic tapestry stimulating every sense. The ring of church bells and honks of early morning traffic echo off the weathered stone of ancient buildings. Office workers dash past fruit stands and sidewalk cafés in the shadows of elegant palace façades. Meanwhile, tourists make their way from piazza to piazza, monument to monument, church to church: the Colosseum, the Roman Forum, the Vatican Museums, St. Peter’s Basilica.

This postcard-perfect destination, with its pastel-colored houses encircling the port, may be one of the most photographed in all of Italy. If you can take your eyes off the scenery, there is much to explore in and around Portofino. The 12th-century Church of St. George and the medieval Castello Brown both afford spectacular views of the harbor. A long, scenic hike or a short boat ride takes you to the restored 11th-century abbey in San Fruttuoso. Northwest of Portofino lies Genoa, filled with museums, palaces and the grand Cathedral of San Lorenzo.

The capital of the Balearic Islands, beautiful Palma is famous for La Seu, the massive Cathedral of Santa Maria overlooking the bay. The adjacent Alumdaina Palace has been a royal residence since the 14th century, and the Gothic-style Bellver Castle houses the city's history museum. The Juan March Foundation Museum boasts a permanent collection of 70 works by the most important Spanish vanguard artists of the 20th century.

The Venetians left their mark in Nafplio. Perched on a cliff jutting into the sea, their impregnable fortress is an elegant display of Venetian might. Walk through the Old Town with its handsome neoclassical buildings and balconies dripping with bougainvillea. One of the most beautiful towns in Greece, Nafplio is also one of the most historic; its cultural roots date back to both the Argonautic expedition and the Trojan War. From here you can drive across the Peloponnese where tales from Homer’s Iliad come alive.

Bronze bodies bask in the sun on golden beaches, blue-domed churches dot the island, and picturesque windmills paddle the horizon. This is Mykonos, one of the most charming and fashionable of the Greek isles. Chora, its capital, is a cubist jumble of whitewashed houses and a maze of alleyways built long ago to foil pirates. Get lost in these narrow, twisting lanes filled with exclusive boutiques, art galleries and world-class restaurants.

Perhaps no port of call is better designed to welcome a luxury yacht than Monte Carlo, where some of the most splendid vessels in the world make their home. At this playground for the rich and famous, the only thing more spectacular than the yachts filling the harbor are the luxury cars driving the winding streets that host the annual Grand Prix. Verdant mountains ascend abruptly behind the lavish high-rises lining the bay, and perched on the cliff is the Palace of the Prince, where the Changing of the Guard attracts onlookers each morning at 11:55.

Founded in 600 BC, Marseille is the oldest city in France and its third largest metropolitan area. A must-see is the 19th-century basilica, Notre Dame de la Garde, which sits at the highest point in the city. Also worth a visit is the water fountain at Palais Longchamp, built under the reign of Napoleon III. Marseille is considered the birthplace of bouillabaisse, so make time to stop for a bowl of this famous seafood stew in the Old Port.

Tall hotels rise up from the golden beaches in Málaga, the historic enclave on the Costa del Sol. While the Mediterranean bathes its coastline, Málaga's mountains back the city to form a cocoon that ensures mild weather. Málaga is among the world's oldest cities, founded 2,800 years ago and settled by Phoenicians, Greeks, Carthaginians, Romans, Byzantines, Visigoths and Christians. Looming over the skyline are the citadels Alcazaba and Castle of Gibralfaro, remnants of Moorish rule. Málaga was revitalized in recent years, now featuring some 30 museums and an edgy urban art community.